PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MIP	1	CRYAB	0	fluorescent resonance energy transfe	Liu BF (2008)	1
CRYAA	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
CRYAA	0	HSPB2	1	two hybrid, affinity chromatography technology	Fu L (2003), Fu L (2003)	2
CRYGC	0	CRYGD	1	two hybrid	Fu L (2003)	1
CRYAB	0	HSPB1	2	biochemical, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Kato K (1992), Kato K (1992), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003), MacIntyre DA (2008), Zhang H (2010), Delbecq SP (2012), Aquilina JA (2013), DeGrado-Warren J (2008), Huttlin EL (2015), Huttlin EL (2017)	13
CRYAA	0	CRYGD	1	two hybrid, pull down	Fu L (2003), Moreau KL (2012)	2
CRYAA	0	SPG21	0	two hybrid	Rolland T (2014)	1
CRYAA	0	CRYAA	0	two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, pull down	Fu L (2002), Zhang X (2007), Fu L (2003), Fu L (2003), Wu M (2012), Fujii N (2008), Rolland T (2014), Validandi V (2011)	8
CRYAA	0	CRYBB2	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003)	4
CRYAA	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CRYAB	0	CRYGD	1	two hybrid, pull down, pull down, pull down	Fu L (2003), Banerjee PR (2011), Ghosh JG (2005), Moreau KL (2012)	4
CRYAA	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CRYAA	0	CRYBA1	0	pull down, imaging technique, two hybrid, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Gupta R (2009), Gupta R (2009), Gupta R (2009), Gupta R (2009), Tiwary E (2015), Tiwary E (2015)	6
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CRYAA	0	GORASP2	1	two hybrid	Rolland T (2014)	1
CRYAB	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
CRYAB	0	CRYBB2	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Ghosh JG (2005)	5
CRYBB2	1	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003)	4
MIP	1	CRYBB2	1	fluorescent resonance energy transfe	Liu BF (2008)	1
CRYAA	0	WDYHV1	0	two hybrid	Rolland T (2014)	1
CRYAA	0	SDCBP	0	two hybrid	Rolland T (2014)	1
MIP	1	CRYGC	0	fluorescent resonance energy transfe	Liu BF (2008)	1
CRYAB	0	HSPB2	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid	Sugiyama Y (2000), Sugiyama Y (2000), Fu L (2003), Fu L (2003), Delbecq SP (2012), Aquilina JA (2013), Grose JH (2015)	7
CRYAA	0	CRYAB	0	two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe	Fu L (2002), Fu L (2002), Fu L (2002), Sreelakshmi Y (2005), Fu L (2003), Fu L (2003), Fu L (2003), Fu L (2003), Rao G (2008), Biswas A (2007), Wu M (2012), Wu M (2012), Fujii N (2008), Fujii N (2008), Sreelakshmi Y (2006), Delbecq SP (2012), Rolland T (2014), Validandi V (2011), Ramkumar S (2015), Tiwary E (2015), Tiwary E (2015)	21
HSPB1	2	CRYBB2	1	two hybrid, affinity chromatography technology	Fu L (2002), Fu L (2002)	2
CRYAB	0	CRYBA1	0	pull down, imaging technique, two hybrid, fluorescent resonance energy transfe	Gupta R (2009), Gupta R (2009), Gupta R (2009), Gupta R (2009)	4
HSPB1	2	CRYAA	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	4
CRYAB	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
MIP	1	CRYAA	0	fluorescent resonance energy transfe	Liu BF (2008)	1
CRYGC	0	HSPB2	1	two hybrid	Fu L (2003)	1
BCL2L1	0	BAX	3	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Strobel T (1998), Zhang H (2002), Gillissen B (2003), Ren H (2011), Ren H (2011), Chinnaiyan AM (1997), Diaz JL (1997), Wang X (2009), Wang X (2009), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Tong J (2017), Huttlin EL (2017), Kim EM (2014)	17
CRYGC	0	HSPB1	2	two hybrid	Fu L (2003)	1