PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBAP1	2	VPS37A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Wunderley L (2014), Stefani F (2011), Huttlin EL (2017)	6
VPS37A	4	TSG101	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Bache KG (2004), Bache KG (2004), Stuchell MD (2004), Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Rolland T (2014), Stefani F (2011), Albers M (2005)	9
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
ALG2	2	VPS37A	4	affinity chromatography technology	Katoh K (2005)	1
UBC	7	VPS28	2	affinity chromatography technology, pull down	Bishop N (2002), Zhang X (2017)	2
UBC	7	UBAP1	2	pull down, pull down, pull down, pull down	Fenner BJ (2009), Stefani F (2011), Kharitidi D (2015), Zhang X (2017)	4
ARRDC1	4	TSG101	1	pull down, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), Rauch S (2011), Nabhan JF (2012), Nabhan JF (2012)	4
HNRNPL	3	VPS37A	4	affinity chromatography technology	Fei T (2017)	1
ALG2	2	VPS28	2	affinity chromatography technology	Katoh K (2005)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
VPS28	2	MVB12A	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
UBC	7	VPS37A	4	pull down	Zhang X (2017)	1
MVB12A	0	VPS37A	4	affinity chromatography technology	Tsunematsu T (2010)	1
VPS37A	4	TRIM42	0	two hybrid	Rolland T (2014)	1
VPS28	2	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Huttlin EL (2015), Huttlin EL (2017)	5
XPO1	8	VPS37A	4	affinity chromatography technology	Kirli K (2015)	1
VPS28	2	MVB12B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	MVB12A	0	affinity chromatography technology	Kirli K (2015)	1
KDM1A	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
MVB12A	0	APP	1	pull down	Olah J (2011)	1
XPO1	8	UBAP1	2	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSG101	1	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Stefani F (2011), Agromayor M (2012), Agromayor M (2012), Wunderley L (2014), Wunderley L (2014), Wunderley L (2014), Wan C (2015), Kharitidi D (2015), Huttlin EL (2017)	10
ALG2	2	TSG101	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Okumura M (2009), Katoh K (2005), Katoh K (2005), Inuzuka T (2010)	4
ARRDC1	4	APP	1	pull down	Olah J (2011)	1
XPO1	8	VPS28	2	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	VPS37A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MVB12A	0	MVB12B	2	affinity chromatography technology, affinity chromatography technology	Tsunematsu T (2010), Tsunematsu T (2010)	2
MVB12B	2	TSG101	1	affinity chromatography technology	Tsunematsu T (2010)	1
MVB12B	2	VPS37A	4	affinity chromatography technology	Tsunematsu T (2010)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
XPO1	8	ARRDC1	4	affinity chromatography technology	Kirli K (2015)	1
MVB12A	0	TSG101	1	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Tsunematsu T (2010), Wunderley L (2014), Wunderley L (2014), Wan C (2015)	4
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
VPS37A	4	VPS28	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bache KG (2004), Bache KG (2004), Bache KG (2004), Bache KG (2004), Stefani F (2011), Huttlin EL (2015), Huttlin EL (2017)	7
ARRDC1	4	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS37A	4	KDM1A	2	two hybrid	Weimann M (2013)	1
VPS37A	4	APP	1	pull down	Olah J (2011)	1