PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPRC	1	PLK3	0	affinity chromatography technology	Xie S (2001)	1
BUB1B	0	TRIP13	0	affinity chromatography technology, pull down	Wang K (2014), Miniowitz-Shemtov S (2015)	2
PLK3	0	BUB1B	0	pull down, affinity chromatography technology	Huang X (2004), Huang X (2004)	2
PLK3	0	BCL2L1	0	enzymatic study	Wang J (2012)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
PLK3	0	SNCB	0	enzymatic study	Mbefo MK (2010)	1
PLK3	0	POU2F1	5	two hybrid	Rolland T (2014)	1
PLK3	0	CDC25C	0	enzymatic study, affinity chromatography technology, pull down	Ouyang B (1999), Ouyang B (1999), Ouyang B (1999)	3
PLK3	0	CENPU	0	unspecified method	Yun SM (2009)	1
CIB1	2	PLK3	0	affinity chromatography technology	Holtrich U (2000)	1
BCL2L1	0	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vinayagam A (2011), Tang WH (2014), Saxena R (2016), Stegh AH (2010), Kim EM (2014)	5
PLK3	0	AURKA	1	pull down	Huang X (2004)	1
AURKA	1	BCL2L1	0	enzymatic study	Wang J (2012)	1
PLK3	0	HIF1A	1	pull down, enzymatic study	Xu D (2010), Xu D (2010)	2
SNCB	0	SNCA	0	affinity chromatography technology	Hashimoto M (2001)	1
CHEK2	2	CDC25C	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Eymin B (2006), Xu X (2002), Yang S (2002), Zannini L (2003), Buscemi G (2001), Zhou BB (2000), Magni M (2014), Wu X (2001), Fujimoto H (2006)	9
PLK3	0	TRIP13	0	two hybrid	Rual JF (2005)	1
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
PRNP	4	PLK3	0	pull down, affinity chromatography technology, affinity chromatography technology	Satoh J (2009), Satoh J (2009), Satoh J (2009)	3
TP53	0	AURKA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Katayama H (2004), Katayama H (2004), Katayama H (2004), Katayama H (2004), Hsueh KW (2013), Huttlin EL (2015), Huttlin EL (2017)	12
PLK3	0	SNCA	0	enzymatic study	Mbefo MK (2010)	1
PLK3	0	TP53	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xie S (2001), Xie S (2001), Bahassi el M (2002), Bahassi el M (2002)	4
HIF1A	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PLK3	0	CHEK2	2	enzymatic study, affinity chromatography technology	Bahassi el M (2002), Bahassi el M (2002)	2