Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ADH1A	124	CYTARABINE	CHEMBL803		PharmGKB
ADH1A	124	FOMEPIZOLE	CHEMBL1308	inhibitor	TdgClinicalTrial, ChemblInteractions, TEND, DrugBank	16790752, 2789998, 19458366, 8997246, 16946442, 16871118
ADH1A	124	CYCLOBUTYL(CYCLOPENTYL)FORMAMIDE	CHEMBL45844		DrugBank	17139284, 17016423, 10592235
ADH1A	124	CHEMBL1161866	CHEMBL1161866		DrugBank	16897483, 16760478
ADH1A	124	ALCOHOL	CHEMBL545		PharmGKB
ADH1A	124	GEMTUZUMAB OZOGAMICIN	CHEMBL1201506		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ADH1A	rs1229976	CT	acetaldehyde	metabolism/PK	yes	Blood concentrations of acetaldehyde, a metabolite of ethanol, were significantly higher in CT individuals compared to TT from 15 minutes to 240 minutes following dosing with alcohol.	Genotype CT is associated with increased concentrations of acetaldehyde in healthy individuals as compared to genotype TT.	31002879	1450936711
ADH1A	rs2276332	C	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele C is associated with metabolism of ethanol.	19193628	827566630
ADH1A	rs6811453	A	cytarabine	efficacy	yes	rs6811453 was in linkage with rs1826909, another SNP in ADH1A.	Allele A is associated with increased resistance to cytarabine, fludarabine, gemtuzumab ozogamicin and idarubicin in people with Leukemia, Myeloid, Acute as compared to allele G.	22584460	827920220
ADH1A	rs1826909	T	cytarabine	efficacy	yes	rs1826909 was in linkage with rs6811453, another SNP in ADH1A.	Allele T is associated with increased resistance to cytarabine, fludarabine, gemtuzumab ozogamicin and idarubicin in people with Leukemia, Myeloid, Acute as compared to allele C.	22584460	827920229
ADH1A	rs931635	A	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele A is associated with metabolism of ethanol.	19193628	827566652
ADH1A	rs1229967	C	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele C is associated with metabolism of ethanol.	19193628	827566637
ADH1A	rs1229976	C	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele C is associated with metabolism of ethanol.	19193628	827566623
ADH1A	rs1229976	CT	ethanol	metabolism/PK	no	No significant difference in blood alcohol concentrations (BAC) over time between different genotypes.	Genotype CT is not associated with concentrations of ethanol in healthy individuals as compared to genotype TT.	31002879	1450936684