Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADCY9 rs144315541 AG salbutamol efficacy yes The allele associated with increased response and low frequency is not explicitly stated. Response is increased for carriers of the rare, minor allele. GALAII genotyping was done using the Affymetrix LAT1 Array, which was designed to capture Latino population variation. This was assessed as a replication attempt for a previously reported association of a different ADCY9 SNP with response to bronchodilators. Bonferroni correction was performed according to the number of SNPs included that are within 50 kb up and downstream of ADCY9. Genotype AG is associated with increased response to salbutamol in children with Asthma as compared to genotype GG. 23992748 1183680156
ADCY9 rs1967309 AA dalcetrapib efficacy yes Part of the dal-OUTCOMES and dal-PLAQUE-2 studies. Outcome was mean change in cholesterol efflux. Patients with the AG genotype had intermediate response. Genotype AA is associated with increased response to dalcetrapib in people with as compared to genotype GG. 27418594 1448125943