PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LYST	8	ZNF521	3	two hybrid	Tchernev VT (2002)	1
YWHAQ	0	MYH13	9	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
GAR1	0	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	MRPL17	0	two hybrid	Tchernev VT (2002)	1
MRPS31	1	DAP3	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
SAP30	1	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	CSNK2B	5	two hybrid, pull down	Tchernev VT (2002), Tchernev VT (2002)	2
TACC1	2	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	YWHAB	1	two hybrid	Tchernev VT (2002)	1
LYST	8	YWHAZ	1	pull down	Tchernev VT (2002)	1
YWHAB	1	HGS	5	affinity chromatography technology	Couzens AL (2013)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
LYST	8	CENPJ	6	two hybrid	Tchernev VT (2002)	1
YWHAB	1	KIF1C	0	affinity chromatography technology	Couzens AL (2013)	1
DAP3	1	LYST	8	affinity chromatography technology	Hein MY (2015)	1
HNRNPH2	2	HNRNPM	1	affinity chromatography technology	Hein MY (2015)	1
LYST	8	DNAJC14	1	two hybrid	Tchernev VT (2002)	1
LYST	8	HNRNPM	1	two hybrid	Tchernev VT (2002)	1
LYST	8	ESRRA	2	two hybrid	Tchernev VT (2002)	1
SAP30	1	GAR1	0	affinity chromatography technology	Hein MY (2015)	1
PPIA	0	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	ESS2	0	two hybrid	Tchernev VT (2002)	1
LYST	8	ATN1	2	two hybrid	Tchernev VT (2002)	1
KLC3	3	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	PCBP4	2	two hybrid	Tchernev VT (2002)	1
YWHAZ	1	CENPJ	6	two hybrid	Bandyopadhyay S (2010)	1
MLH1	6	LYST	8	affinity chromatography technology	Hein MY (2015)	1
HNRNPH2	2	LYST	8	affinity chromatography technology	Hein MY (2015)	1
ATN1	2	CENPJ	6	two hybrid	Lim J (2006)	1
LYST	8	NCDN	4	two hybrid	Tchernev VT (2002)	1
LYST	8	YWHAQ	0	two hybrid	Tchernev VT (2002)	1
MLH1	6	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
LYST	8	CNTROB	6	two hybrid	Tchernev VT (2002)	1
CENPJ	6	YWHAB	1	affinity chromatography technology	Hein MY (2015)	1
LYST	8	EFS	2	two hybrid	Tchernev VT (2002)	1
KIF1C	0	LYST	8	affinity chromatography technology	Hein MY (2015)	1
KIF1C	0	YWHAQ	0	two hybrid	Wang J (2011)	1
LYST	8	KPNB1	3	two hybrid	Tchernev VT (2002)	1
LYST	8	MED12	11	two hybrid	Tchernev VT (2002)	1
LYST	8	CELF4	2	two hybrid	Tchernev VT (2002)	1
LYST	8	MRPS31	1	two hybrid	Tchernev VT (2002)	1
LYST	8	HGS	5	two hybrid, pull down	Tchernev VT (2002), Tchernev VT (2002)	2
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
MYH13	9	LYST	8	affinity chromatography technology	Hein MY (2015)	1
LYST	8	TNNI3	0	two hybrid	Tchernev VT (2002)	1
KIF1C	0	YWHAZ	1	two hybrid	Wang J (2011)	1
LYST	8	VTA1	1	two hybrid	Tchernev VT (2002)	1
LLGL2	4	LYST	8	affinity chromatography technology	Hein MY (2015)	1