Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ALDH1L1	10840	TETRAHYDROFOLATE	CHEMBL2074655	cofactor	DrugBank	16627483, 11320079, 10395731, 16712799, 10585460

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ALDH1L1	rs2886059	C	methylphenidate	efficacy	no	The authors carried out a GWAS in a Spanish cohort of pediatric patients, than performed a meta-analysis using data from the Spanish cohort and data from a Brazilian adult patient cohort. This variant was not significant in the meta-analysis after Bonferroni correction had been applied, and was nominally significant (i.e did not reach genome-wide significance) in the initial GWAS in the Spanish cohort. Response was measured on the Clinical Global Impression-Improvement scale (CGI-I). A CGI-I score of two points or less after eight weeks of treatment was considered a good response.	Allele C is associated with increased response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity.	29382897	1449166044