PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STX4	2	SNAP29	1	pull down	Steegmaier M (1998)	1
SNAP29	1	VAMP5	0	two hybrid	Rolland T (2014)	1
STX16	1	VAMP5	0	two hybrid	Rolland T (2014)	1
LMNA	2	STX4	2	two hybrid	Dittmer TA (2014)	1
STX1A	2	SNAP23	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid	Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Ravichandran V (1996), Steegmaier M (1998), Corominas R (2014)	7
ATP4A	6	VAMP5	0	affinity chromatography technology	Lapierre LA (2007)	1
STX4	2	VAMP5	0	two hybrid	Rolland T (2014)	1
LMNA	2	VAMP5	0	two hybrid	Dittmer TA (2014)	1
STX1A	2	SNAP29	1	pull down, two hybrid	Steegmaier M (1998), Corominas R (2014)	2
STX4	2	SNAP23	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical	Imai A (2003), Imai A (2003), Imai A (2003), Li G (2003), Araki S (1997), Araki S (1997), Araki S (1997), Paumet F (2000), Paumet F (2000), Ravichandran V (1996), Kawanishi M (2000), Kawanishi M (2000), Steegmaier M (1998), Freedman SJ (2003), Havugimana PC (2012)	15
MDC1	8	VAMP5	0	two hybrid	Woods NT (2012)	1
STX4	2	STX16	1	two hybrid	Rolland T (2014)	1
STX1A	2	VAMP5	0	two hybrid	Corominas R (2014)	1
SNAP23	0	VAMP5	0	two hybrid	Rolland T (2014)	1
LMNA	2	MDC1	8	bioid	Roux KJ (2012)	1