PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRMT1	3	FUS	0	enzymatic study, enzymatic study, two hybrid, affinity chromatography technology	Wada K (2002), Lee J (2002), Stelzl U (2005), Wang T (2014)	4
PTCH1	8	KHDRBS3	0	affinity chromatography technology	Yamaki Y (2016)	1
KHDRBS2	1	PRMT1	3	affinity chromatography technology	Jeronimo C (2007)	1
RBMX	2	KHDRBS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Jeronimo C (2007), Rolland T (2014)	4
KHDRBS1	1	PPP1R13B	9	unspecified method, two hybrid, far western blotting	Asbach B (2012), Thornton JK (2006), Thornton JK (2006)	3
KHDRBS1	1	SYNCRIP	6	biochemical	Wan C (2015)	1
BMI1	0	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
U2AF2	7	IFI16	1	affinity chromatography technology	Whisenant TC (2015)	1
KHDRBS3	0	PRPF31	0	two hybrid	Rolland T (2014)	1
RPAP2	3	PRPF31	0	affinity chromatography technology	Jeronimo C (2007)	1
RPAP2	3	KHDRBS3	0	affinity chromatography technology	Jeronimo C (2007)	1
BMI1	0	NCOA5	1	affinity chromatography technology	Cao Q (2014)	1
SIAH1	2	KHDRBS3	0	two hybrid, two hybrid, pull down, two hybrid	Rual JF (2005), Venables JP (2004), Venables JP (2004), Buchwald M (2012)	4
FUS	0	RBMX	2	two hybrid	Wang J (2011)	1
NCOA5	1	KHDRBS2	1	two hybrid	Rolland T (2014)	1
FBXW11	2	FUS	0	affinity chromatography technology	Low TY (2014)	1
HNRNPK	4	PRMT1	3	affinity chromatography technology, enzymatic study	Cote J (2003), Wada K (2002)	2
BMI1	0	KHDRBS1	1	affinity chromatography technology	Cao Q (2014)	1
YTHDC1	8	KHDRBS2	1	two hybrid	Rolland T (2014)	1
SYNCRIP	6	U2AF2	7	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015), Whisenant TC (2015)	3
KHDRBS1	1	RBMX	2	two hybrid	Wang J (2011)	1
KHDRBS3	0	ATXN2	3	biochemical	Wan C (2015)	1
KHDRBS3	0	YTHDC1	8	two hybrid	Rolland T (2014)	1
KHDRBS3	0	FBXO32	2	affinity chromatography technology	Lei KF (2011)	1
PTCH1	8	KHDRBS1	1	affinity chromatography technology	Yamaki Y (2016)	1
U2AF2	7	KHDRBS1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Whisenant TC (2015), Whisenant TC (2015)	4
FUS	0	HNRNPK	4	affinity chromatography technology	Wang T (2014)	1
KHDRBS1	1	HNRNPK	4	two hybrid, pull down, affinity chromatography technology, pull down, genetic interference, genetic interference, two hybrid, two hybrid, two hybrid	Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Hegele A (2012), Hegele A (2012), Wang J (2011)	9
FBXO7	1	KHDRBS3	0	enzymatic study	Teixeira FR (2016)	1
SNRPC	0	KHDRBS3	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
KHDRBS3	0	NUDT18	0	two hybrid	Rual JF (2005)	1
KHDRBS3	0	KHDRBS3	0	two hybrid, two hybrid	Hegele A (2012), Rolland T (2014)	2
SERPINB5	0	KHDRBS3	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Lei KF (2011), Lei KF (2011), Lei KF (2011)	3
FBXW11	2	KHDRBS3	0	affinity chromatography technology	Low TY (2014)	1
CACNA1A	21	KHDRBS3	0	two hybrid	Kahle JJ (2011)	1
HNRNPK	4	RBM7	2	two hybrid	Rual JF (2005)	1
KHDRBS2	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
HNRNPK	4	MARK4	6	two hybrid	Rolland T (2014)	1
INPP5D	2	KHDRBS3	0	two hybrid	Rolland T (2014)	1
SIAH1	2	PRPF31	0	two hybrid	Rolland T (2014)	1
IFI16	1	FBXW11	2	affinity chromatography technology	Diner BA (2015)	1
KHDRBS2	1	HNRNPR	3	affinity chromatography technology, two hybrid, biochemical	Jeronimo C (2007), Rolland T (2014), Wan C (2015)	3
BMI1	0	YTHDC1	8	affinity chromatography technology	Cao Q (2014)	1
G3BP1	4	RPAP2	3	affinity chromatography technology	Sowa ME (2009)	1
HNRNPK	4	KHDRBS2	1	two hybrid, affinity chromatography technology	Rual JF (2005), Jeronimo C (2007)	2
FBXO7	1	PSMF1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kirk R (2008), Kirk R (2008), Kirk R (2008), Kirk R (2008), Kirk R (2008), Rolland T (2014), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016)	10
SGSM2	2	KHDRBS3	0	two hybrid	Stelzl U (2005)	1
U2AF2	7	NCOA5	1	affinity chromatography technology	Whisenant TC (2015)	1
NELFB	7	KHDRBS3	0	pull down	Miyamoto-Sato E (2010)	1
RBBP6	7	FBXO7	1	two hybrid	Wang J (2008)	1
KHDRBS3	0	DMRT3	2	two hybrid	Rolland T (2014)	1
KHDRBS2	1	SYNCRIP	6	affinity chromatography technology, biochemical	Jeronimo C (2007), Wan C (2015)	2
HNRNPK	4	RBMX	2	two hybrid, biochemical, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Rolland T (2014), Yu H (2011)	6
PTCH1	8	KHDRBS2	1	affinity chromatography technology	Yamaki Y (2016)	1
KHDRBS1	1	YTHDC1	8	affinity chromatography technology, two hybrid	Hartmann AM (1999), Hartmann AM (1999)	2
KHDRBS3	0	SYNCRIP	6	biochemical	Wan C (2015)	1
BMI1	0	KHDRBS3	0	affinity chromatography technology	Cao Q (2014)	1
PRPF31	0	KHDRBS2	1	two hybrid	Rolland T (2014)	1
FBXW11	2	RBMX	2	affinity chromatography technology	Low TY (2014)	1
RBMX	2	HNRNPR	3	biochemical	Havugimana PC (2012)	1
RBMX	2	LNX1	7	two hybrid	Rual JF (2005)	1
RBMX	2	NCOA5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPC	0	RBMX	2	biochemical	Havugimana PC (2012)	1
PRMT1	3	SYNCRIP	6	enzymatic study, affinity chromatography technology, two hybrid	Wada K (2002), Weimann M (2013), Weimann M (2013)	3
HNRNPK	4	U2AF2	7	biochemical, two hybrid, two hybrid, affinity chromatography technology	Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Whisenant TC (2015)	4
KHDRBS3	0	BAHD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KHDRBS3	0	KHDRBS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Jeronimo C (2007), Huttlin EL (2017)	3
FBXW11	2	HNRNPR	3	affinity chromatography technology	Coyaud E (2015)	1
KHDRBS3	0	RBMX	2	two hybrid	Rual JF (2005)	1
RBM7	2	KHDRBS1	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
NELFB	7	SYNCRIP	6	biochemical	Kristensen AR (2012)	1
PTBP2	1	KHDRBS3	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
KHDRBS3	0	MARK4	6	two hybrid	Rolland T (2014)	1
HNRNPK	4	HNRNPR	3	biochemical	Havugimana PC (2012)	1
HNRNPK	4	PRPF31	0	two hybrid	Rolland T (2014)	1
RBM7	2	KHDRBS3	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
FUS	0	PTBP2	1	affinity chromatography technology	Meissner M (2003)	1
FBXO7	1	PRPF31	0	affinity chromatography technology	Teixeira FR (2016)	1
G3BP1	4	SYNCRIP	6	affinity chromatography technology	Jain S (2016)	1
HNRNPR	3	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
FUS	0	SYNCRIP	6	affinity chromatography technology	Wang T (2014)	1
G3BP1	4	KHDRBS3	0	affinity chromatography technology	Jain S (2016)	1
FBXW11	2	YTHDC1	8	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPK	4	KHDRBS3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Hegele A (2012), Hegele A (2012)	3
FBXO7	1	HNRNPK	4	affinity chromatography technology, enzymatic study	Teixeira FR (2016), Teixeira FR (2016)	2
PSMF1	0	KHDRBS3	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
FBXW11	2	KHDRBS1	1	affinity chromatography technology	Low TY (2014)	1
KHDRBS3	0	LNX1	7	two hybrid	Rual JF (2005)	1
SYNCRIP	6	HNRNPR	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
G3BP1	4	ATXN2	3	affinity chromatography technology	Jain S (2016)	1
KHDRBS1	1	PRMT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cote J (2003), Cote J (2003), Mitchell TR (2009), Cheung N (2007), Robin-Lespinasse Y (2007)	5
KHDRBS3	0	KHDRBS1	1	two hybrid, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Thornton JK (2006)	3
KHDRBS2	1	ATXN2	3	biochemical	Wan C (2015)	1
HNRNPC	0	KHDRBS3	0	two hybrid	Xin X (2009)	1
RBM7	2	RBMX	2	two hybrid	Rual JF (2005)	1
FBXO7	1	PRMT1	3	affinity chromatography technology, enzymatic study	Hein MY (2015), Teixeira FR (2016)	2
PTCH1	8	PRMT1	3	affinity chromatography technology	Yamaki Y (2016)	1
HNRNPR	3	KHDRBS1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPK	4	SYNCRIP	6	biochemical, two hybrid, two hybrid	Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	3
KHDRBS3	0	PPP1R13B	9	far western blotting	Thornton JK (2006)	1
RBBP6	7	KHDRBS3	0	two hybrid	Wang J (2008)	1
FUS	0	KHDRBS3	0	two hybrid	Wang J (2011)	1
BMI1	0	ATXN2	3	affinity chromatography technology	Cao Q (2014)	1
HNRNPC	0	KHDRBS1	1	biochemical	Havugimana PC (2012)	1
KHDRBS1	1	ATXN2	3	biochemical	Wan C (2015)	1
HNRNPK	4	CCDC33	3	two hybrid	Rolland T (2014)	1
IFI16	1	KHDRBS3	0	affinity chromatography technology	Diner BA (2015)	1
HNRNPK	4	YTHDC1	8	two hybrid	Rolland T (2014)	1
HNRNPC	0	HNRNPR	3	biochemical	Havugimana PC (2012)	1
KHDRBS3	0	CCDC33	3	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
RPAP2	3	KHDRBS2	1	affinity chromatography technology	Jeronimo C (2007)	1
KHDRBS2	1	HNRNPC	0	affinity chromatography technology	Jeronimo C (2007)	1
IFI16	1	YTHDC1	8	affinity chromatography technology	Diner BA (2015)	1
SERPINB5	0	FBXO32	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Lei KF (2011), Lei KF (2011), Lei KF (2011)	3
G3BP1	4	PRMT1	3	affinity chromatography technology	Jain S (2016)	1
FBXW11	2	HNRNPC	0	affinity chromatography technology	Huttlin EL (2017)	1
PTBP2	1	KHDRBS1	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PRMT1	3	HNRNPR	3	enzymatic study, two hybrid, two hybrid	Wada K (2002), Stelzl U (2005), Rolland T (2014)	3
PSMF1	0	RBMX	2	two hybrid	Rual JF (2005)	1
BMI1	0	FUS	0	affinity chromatography technology	Cao Q (2014)	1
KHDRBS2	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
U2AF2	7	RBMX	2	affinity chromatography technology	Whisenant TC (2015)	1
KHDRBS3	0	HNRNPR	3	biochemical	Wan C (2015)	1
HNRNPC	0	PTBP2	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
HNRNPC	0	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
RBMX	2	CCDC33	3	two hybrid	Rual JF (2005)	1
FBXW11	2	SYNCRIP	6	affinity chromatography technology	Coyaud E (2015)	1
RBMX	2	YTHDC1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KHDRBS3	0	NCOA5	1	two hybrid	Rolland T (2014)	1
U2AF2	7	KHDRBS3	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
KHDRBS3	0	PRMT1	3	affinity chromatography technology	Cote J (2003)	1
KHDRBS3	0	ZNF408	0	two hybrid	Rual JF (2005)	1