PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
8339	0	RAD51AP1	1	bioid	Lambert JP (2015)	1
RAD51AP1	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RAD51	3	RAD51AP1	1	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down	Kovalenko OV (1997), Kovalenko OV (1997), Kovalenko OV (1997), Henson SE (2006), Liang F (2016)	5
USP12	1	APP	1	pull down	Olah J (2011)	1
WDR48	2	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Lee KY (2010), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Villamil MA (2012), Garcia-Santisteban I (2012), Garcia-Santisteban I (2012), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Cohn MA (2007), Lehoux M (2014), Lehoux M (2014), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016)	25
USP1	4	JUP	7	affinity chromatography technology	Sowa ME (2009)	1
USP12	1	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Jahan AS (2016), McClurg UL (2015), Dharadhar S (2016), Cukras S (2016), Li H (2016), Li H (2016), Gangula NR (2013)	15
RAD51AP1	1	JUP	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
8339	0	PALB2	3	bioid	Lambert JP (2015)	1
PALB2	3	RAD51AP1	1	pull down	Dray E (2010)	1
MAP3K1	4	RAD51AP1	1	enzymatic study	Charlaftis N (2014)	1
USP12	1	RAD51AP1	1	affinity chromatography technology	Sowa ME (2009)	1
SIAH1	2	RAD51AP1	1	two hybrid	Rolland T (2014)	1
RAD51AP1	1	3503	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP46	5	USP12	1	affinity chromatography technology, bioid	Sowa ME (2009), Jahan AS (2016)	2
WDR48	2	RAD51	3	pull down	Liang F (2016)	1
RAD51AP1	1	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Huttlin EL (2017)	4
RAD51AP1	1	3501	0	affinity chromatography technology	Huttlin EL (2015)	1
PALB2	3	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dray E (2010), Hayakawa T (2010), Zhang F (2009), Zhang F (2009), Xia B (2006), Anantha RW (2013), Bleuyard JY (2012), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Foo TK (2017), Foo TK (2017)	18
WDR48	2	RAD51AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016), Liang F (2016), Liang F (2016)	9
USP46	5	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Huttlin EL (2015), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Yin J (2015), Cukras S (2016), Huttlin EL (2017)	14
RAD51AP1	1	3502	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP46	5	RAD51AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
NEDD4	2	RAD51AP1	1	enzymatic study	Persaud A (2009)	1