PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	DRAP1	2	enzymatic study	Teixeira FR (2016)	1
DR1	1	POLE3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DRAP1	2	POLE3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DRAP1	2	SUMO3	0	biochemical	Kristensen AR (2012)	1
POLE3	0	APP	1	pull down	Olah J (2011)	1
PLEKHF2	1	APP	1	pull down	Olah J (2011)	1
DRAP1	2	PLEKHF2	1	two hybrid	Yu H (2011)	1
ZEB1	3	DRAP1	2	two hybrid	Ikeda K (1998)	1
MRPS11	1	DRAP1	2	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	TPD52L2	0	two hybrid	Wang J (2011)	1
FOXK2	9	TBP	0	affinity chromatography technology	Li X (2015)	1
DRAP1	2	TAF9B	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
FEZ2	0	DRAP1	2	two hybrid	Assmann EM (2006)	1
DRAP1	2	APP	1	pull down	Olah J (2011)	1
TK1	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
DRAP1	2	TPD52L2	0	biochemical	Kristensen AR (2012)	1
TBP	0	TAF9	2	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Bellorini M (1997), Martinez E (2001), Knuesel MT (2009), Liu X (2008), Havugimana PC (2012)	5
RAD23B	1	SUMO3	0	biochemical	Wan C (2015)	1
TAF9	2	APP	1	pull down	Olah J (2011)	1
DRAP1	2	DR1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid	Yeung K (1997), Mermelstein F (1996), Mermelstein F (1996), Gilfillan S (2005), Wang YL (2008), Havugimana PC (2012), Wan C (2015), Wang YL (2008), Vo TV (2016)	9
FOXD3	1	DRAP1	2	affinity chromatography technology	Li X (2015)	1
DRAP1	2	HSPBP1	0	biochemical	Kristensen AR (2012)	1
FOXK2	9	DRAP1	2	affinity chromatography technology	Li X (2015)	1
SRPK2	1	NCK2	2	enzymatic study	Varjosalo M (2013)	1
CDKN2C	0	DRAP1	2	two hybrid	Stelzl U (2005)	1
FEZ1	0	DRAP1	2	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
DR1	1	TBP	0	two hybrid, pull down	Rolland T (2014), Wang YL (2008)	2
HSPBP1	0	APP	1	pull down	Olah J (2011)	1
GTF2B	1	TBP	0	biochemical, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	Scully R (1997), Scully R (1997), Bushnell DA (2004), Friedman MJ (2007), Tsai FT (2000), Bagby S (1995), Lin Y (1997)	7
GTF2B	1	DRAP1	2	two hybrid	Rolland T (2014)	1
TAF9	2	GTF2B	1	two hybrid, pull down, pull down	Muscat GE (1998), Muscat GE (1998), Muscat GE (1998)	3
FEZ1	0	FEZ2	0	two hybrid	Assmann EM (2006)	1
PIK3R3	0	DRAP1	2	two hybrid	Rual JF (2005)	1
TAF9B	0	TBP	0	affinity chromatography technology	Frontini M (2005)	1
NCK2	2	DRAP1	2	two hybrid	Rolland T (2014)	1
TAF9B	0	APP	1	pull down	Olah J (2011)	1
FOXH1	1	DRAP1	2	affinity chromatography technology, pull down	Iratni R (2002), Iratni R (2002)	2
FOXK2	9	SRPK2	1	affinity chromatography technology	Li X (2015)	1
TAF9	2	DRAP1	2	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014), Yu H (2011)	4
SRPK2	1	APP	1	pull down	Olah J (2011)	1
TTF2	4	DRAP1	2	two hybrid	Leonard D (2003)	1
TBP	0	NFYB	2	affinity chromatography technology, pull down	Bellorini M (1997), Bellorini M (1997)	2
TNFRSF14	2	APP	1	pull down	Olah J (2011)	1
TAF9	2	FEZ1	0	pull down	Miyamoto-Sato E (2010)	1
DNAJB11	3	DRAP1	2	two hybrid	Vinayagam A (2011)	1
LMO2	2	DRAP1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TK1	0	DRAP1	2	two hybrid	Stelzl U (2005)	1
SRPK2	1	DRAP1	2	enzymatic study	Varjosalo M (2013)	1
TK1	0	APP	1	pull down	Olah J (2011)	1
FBXO7	1	TAF9B	0	enzymatic study	Teixeira FR (2016)	1
DRAP1	2	RAD23B	1	biochemical	Kristensen AR (2012)	1
DRAP1	2	TBP	0	x-ray crystallography, affinity chromatography technology, pull down	Kamada K (2001), Gilfillan S (2005), Wang YL (2008)	3
DRAP1	2	DRAP1	2	two hybrid	Rolland T (2014)	1
TAF9B	0	TAF9	2	affinity chromatography technology	Frontini M (2005)	1
TNFRSF14	2	DRAP1	2	two hybrid	Vinayagam A (2011)	1
NFYB	2	DRAP1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2