PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATF3	0	ATF2	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Ravasi T (2010), Reinke AW (2013), Reinke AW (2013)	3
BATF	0	ATF2	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
CEBPE	0	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	BATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF	0	KDM1A	2	two hybrid	Weimann M (2013)	1
DDIT3	1	JUNB	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	SNAPC5	4	two hybrid	Rolland T (2014)	1
NFIL3	1	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
JUN	0	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	GOPC	5	two hybrid	Rolland T (2014)	1
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CEBPE	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down	Reinke AW (2013), Reinke AW (2013), Reddy KV (2003)	3
CEBPE	0	DDIT3	1	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
BATF	0	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	GOPC	5	affinity chromatography technology	Huttlin EL (2017)	1
BATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
ATF2	1	CEBPA	0	two hybrid	Hong S (2004)	1
BATF	0	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	CEBPG	1	two hybrid, pull down, fluorescent resonance energy transfe	Chih DY (2004), Chih DY (2004), Reinke AW (2013)	3
DBP	1	CEBPG	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
CEBPG	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	ATF4	2	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
ATF3	0	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
CEBPA	0	JUN	0	affinity chromatography technology	Zada AA (2006)	1
DBP	1	CEBPA	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
JUNB	0	BATF	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, two hybrid	Wang X (1996), Reinke AW (2013), Reinke AW (2013), Rolland T (2014), Yu H (2011)	5
DDIT3	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DBP	1	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), Wang J (2011)	3
BATF3	0	BATF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
ATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BATF	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Rual JF (2005), Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	4
JUN	0	GOPC	5	pull down, affinity chromatography technology	Miyamoto-Sato E (2010), Li X (2015)	2
IRF4	1	BATF	0	two hybrid	Ravasi T (2010)	1
CEBPA	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPG	1	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	ATF2	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
BATF	0	CEBPE	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
BATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	KDM1A	2	affinity chromatography technology	Steunou AL (2012)	1
ATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
EPAS1	6	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BATF3	0	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
SNAPC5	4	BATF	0	two hybrid	Rual JF (2005)	1
BATF3	0	CEBPE	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DBP	1	ATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF3	0	JUN	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Pearson AG (2003), Chen BP (1996), Hai T (1991), Filen S (2010), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Li X (2015)	8
EPAS1	6	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	JUN	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
BATF	0	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
JUNB	0	GOPC	5	affinity chromatography technology	Huttlin EL (2017)	1
BATF	0	IFI35	1	two hybrid, pull down	Wang X (1996), Wang X (1996)	2
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
BATF3	0	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	JUNB	0	two hybrid	Wang J (2011)	1
ATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
IFI35	1	KDM1A	2	two hybrid	Weimann M (2013)	1
DDIT3	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	DDIT3	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Hattori T (2003), Rolland T (2014)	3
ATF4	2	ATF2	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
BATF3	0	JUN	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Iacobelli M (2000), Reinke AW (2013), Reinke AW (2013), Li X (2015), Huttlin EL (2017)	5