PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRMT5	3	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004), Migliori V (2012)	4
SMARCA2	17	SIN3A	13	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sif S (2001), Sif S (2001), Pal S (2003), Pal S (2003), Nakamura T (2002), Nakamura T (2002), Kemper JK (2004), Kemper JK (2004), Wan C (2015)	9
PRMT5	3	SREBF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu L (2016), Liu L (2016), Liu L (2016), Liu L (2016)	4
PRMT5	3	CLNS1A	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Krapivinsky G (1998), Friesen WJ (2001), Krapivinsky G (1998), Krapivinsky G (1998), Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Pesiridis GS (2009), Chari A (2008), Chari A (2008), Hegele A (2012), Hegele A (2012)	14
SMARCA2	17	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003)	5
SUPT5H	2	PRMT5	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Kwak YT (2003), Kwak YT (2003), Kwak YT (2003)	3
CLNS1A	2	WDR77	2	affinity chromatography technology	Friesen WJ (2002)	1
GAR1	0	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
PRMT5	3	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, protein complementation assay	Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016)	5
SREBF1	5	CDK8	1	affinity chromatography technology, pull down	Taatjes DJ (2002), Yang F (2006)	2
SMARCA4	19	HIST1H3A	3	pull down, pull down, pull down	Lavigne M (2009), Lavigne M (2009), Kouskouti A (2005)	3
CDK8	1	SMARCA2	17	biochemical	Cho H (1998)	1
GAR1	0	WDR77	2	affinity chromatography technology	Hein MY (2015)	1
COPRS	0	PRMT5	3	pull down, two hybrid, pull down, affinity chromatography technology, biochemical	Paul C (2011), Lacroix M (2008), Lacroix M (2008), Lacroix M (2008), Lacroix M (2008)	5
CDK19	1	SMARCA4	19	two hybrid, pull down, pull down	Fukasawa R (2012), Fukasawa R (2012), Fukasawa R (2012)	3
RELA	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei H (2013), Wei H (2013), Yang F (2015)	3
NFE4	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Z (2012), Xu Z (2012), Xu Z (2012)	3
PRMT5	3	PRMT5	3	affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, genetic interference	Rho J (2001), Pollack BP (1999), Hegele A (2012), Antonysamy S (2012), Wong AS (2016)	5
CDK19	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
HOXA9	0	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2012), Bandyopadhyay S (2012), Bandyopadhyay S (2012)	3
GAR1	0	COPRS	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK8	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
HIST1H3A	3	WDR5	2	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006), Schuetz A (2006), Couture JF (2006), Ruthenburg AJ (2006), Han Z (2006), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Bailey JK (2015)	11
NFE4	0	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Q (2009), Xu Z (2012), Xu Z (2012)	3
TRAF4	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozan LM (2006), Yang F (2015), Yang F (2015)	3
WDR5	2	HIST4H4	1	enzymatic study	Kim K (2013)	1
PRMT5	3	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004)	3
STUB1	4	RELA	1	affinity chromatography technology	Wang S (2012)	1
HIST1H3A	3	SMARCA2	17	pull down, pull down	Lavigne M (2009), Lavigne M (2009)	2
PRMT5	3	WDR77	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, biochemical, biochemical, biochemical, two hybrid, affinity chromatography technology	Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Liu F (2011), Aggarwal P (2010), Aggarwal P (2010), Patel SR (2012), Patel SR (2012), Hosohata K (2003), Hegele A (2012), Hegele A (2012), Antonysamy S (2012), Kristensen AR (2012), Wan C (2015), Lacroix M (2008), Saha K (2016)	17
PRMT5	3	WDR5	2	affinity chromatography technology, pull down, biochemical	Xu Z (2012), Xu Z (2012), Xu Z (2012)	3
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
ZNF224	7	PRMT5	3	affinity chromatography technology, affinity chromatography technology, pull down	Cesaro E (2009), Cesaro E (2009), Cesaro E (2009)	3
CDK8	1	SMARCA4	19	pull down, pull down	Fukasawa R (2012), Fukasawa R (2012)	2
CDK19	1	WDR77	2	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
RBM23	0	PRMT5	3	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Hegele A (2012), Hegele A (2012), Weimann M (2013), Weimann M (2013)	4
WDR77	2	SMARCA4	19	affinity chromatography technology	Aggarwal P (2010)	1
CDK8	1	CDK19	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK8	1	WDR77	2	affinity chromatography technology, affinity chromatography technology, pull down	Tsutsui T (2013), Tsutsui T (2013), Tsutsui T (2013)	3
SMARCA4	19	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003), Pal S (2003), Aggarwal P (2010)	6
JAK2	1	PRMT5	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pollack BP (1999), Pollack BP (1999), Liu F (2011), Liu F (2011), Liu F (2011)	5
NFE4	0	CLNS1A	2	affinity chromatography technology	Xu Z (2012)	1
PRMT5	3	SIN3A	13	affinity chromatography technology, pull down, pull down	Pal S (2003), Pal S (2003), Pal S (2003)	3
SMARCA4	19	SMARCA2	17	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Reyes JC (1997), Pal S (2003), Ito T (2008), Ito T (2008), Havugimana PC (2012)	5
PRMT5	3	HIST4H4	1	enzymatic study, unspecified method, enzymatic study	Lacroix M (2008), Burgos ES (2015), Burgos ES (2015)	3
GAR1	0	CLNS1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
SMARCA4	19	SIN3A	13	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sif S (2001), Sif S (2001), Kuzmichev A (2002), Kuzmichev A (2002), Qiu Z (2008), Xu Z (2006), Pal S (2003), Pal S (2003)	8
COPRS	0	HIST4H4	1	pull down	Lacroix M (2008)	1
RELA	1	SMARCA2	17	imaging technique	Ishizaka A (2012)	1