PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
3240	0	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	ZNF160	2	two hybrid	Wang J (2011)	1
ANXA5	0	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	POT1	2	two hybrid	Wang J (2011)	1
CWC25	0	LAMC3	9	two hybrid	Wang J (2011)	1
CFB	1	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	YTHDC1	8	two hybrid	Wang J (2011)	1
KIF1C	0	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	LGMN	0	two hybrid	Wang J (2011)	1
CSNK2A2	1	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	TF	2	two hybrid	Wang J (2011)	1
LAMC3	9	SLC43A3	0	two hybrid	Wang J (2011)	1
CRP	0	LAMC3	9	two hybrid	Wang J (2011)	1
FRAT1	0	LAMC3	9	two hybrid	Wang J (2011)	1
EPB41L4B	2	LAMC3	9	two hybrid	Wang J (2011)	1
LAMC3	9	RPL35	1	two hybrid	Wang J (2011)	1
LAMC3	9	PELI2	5	two hybrid	Wang J (2011)	1
LAMC3	9	NR1H2	2	two hybrid	Wang J (2011)	1
LAMC3	9	SERPINA3	2	two hybrid	Wang J (2011)	1
CYP2E1	0	LAMC3	9	two hybrid	Wang J (2011)	1