PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
EPN1	4	ERBB3	3	affinity chromatography technology	Szymanska M (2016)	1
PVR	1	AP1M2	2	two hybrid	Ohka S (2001)	1
NECAP1	0	AP1G1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mattera R (2004), Mattera R (2004), Bai H (2004)	3
MAST1	9	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
EHD2	3	EPN1	4	affinity chromatography technology	Ko G (2010)	1
EGFR	5	RAB3A	0	protein complementation assay	Deribe YL (2009)	1
SCNN1A	1	SCNN1G	2	affinity chromatography technology	Buck TM (2017)	1
AP1M2	2	AP1B1	6	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
AP1M2	2	AFTPH	4	affinity chromatography technology	Huttlin EL (2017)	1
AP1M2	2	AP1S3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB3	3	AP1M2	2	affinity chromatography technology	Li J (2013)	1
AP1S1	1	AP1G1	8	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Takatsu H (1998), Foelsch H (1999), Page LJ (1995), Havugimana PC (2012), Hirst J (2000), Wan C (2015)	6
AP1S2	1	AP1G1	8	two hybrid, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Takatsu H (1998), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
SCNN1G	2	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	EPN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sigismund S (2005), Bertelsen V (2011), Kazazic M (2009)	3
AP2B1	3	EPN1	4	biochemical	Kristensen AR (2012)	1
AP1S2	1	AFTPH	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
AP1B1	6	AP1S1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
AP1M2	2	NECAP1	0	affinity chromatography technology	Huttlin EL (2015)	1
EGFR	5	AP1M2	2	affinity chromatography technology	Foerster S (2013)	1
AP1M2	2	RIPK1	2	affinity chromatography technology	Huttlin EL (2015)	1
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
SCNN1B	1	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
EGFR	5	MAST1	9	protein complementation assay	Deribe YL (2009)	1
ECSIT	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
AP2B1	3	AP1M2	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
AP1M2	2	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
SCNN1A	1	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
AP1S2	1	AP1G2	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Takatsu H (1998), Hein MY (2015), Huttlin EL (2017)	3
EGFR	5	AP2B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014), Li J (2013)	3
AP1M2	2	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
AP2B1	3	AP1S2	1	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Hein MY (2015), Huttlin EL (2017)	3
EGFR	5	AP1S1	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
AP1G1	8	AP2B1	3	biochemical	Wan C (2015)	1
AP1M2	2	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
ERBB3	3	NDRG1	2	affinity chromatography technology	Verma N (2017)	1
AP1G1	8	AP1M2	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Foelsch H (1999), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
SCNN1B	1	SCNN1G	2	protein complementation assay	Faria D (2012)	1
AP1S1	1	AP1G2	4	two hybrid	Takatsu H (1998)	1
EPN1	4	AP1B1	6	affinity chromatography technology	Mills IG (2003)	1
RAB3D	0	APP	1	pull down	Olah J (2011)	1
AP1M2	2	AP1G2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP1M2	2	EHD2	3	pull down	Park SY (2004)	1
AP1B1	6	AP1G1	8	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Takatsu H (1998), Foelsch H (1999), Page LJ (1995), Havugimana PC (2012), Hirst J (2000), Wan C (2015)	6
MAST1	9	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	AP1S2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP1M2	2	TMF1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	AP1G2	4	affinity chromatography technology	Foerster S (2013)	1
A2M	8	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
AP1S2	1	HEATR5B	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
AP1M2	2	SCNN1B	1	affinity chromatography technology	Wang H (2006)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
AP1M2	2	SCNN1A	1	affinity chromatography technology	Wang H (2006)	1
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
LDLR	4	AP1M2	2	affinity chromatography technology	Foelsch H (2001)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
NDRG1	2	AP1M2	2	affinity chromatography technology	Tu LC (2007)	1
AP1B1	6	AP1S2	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
AP2B1	3	AP1S1	1	biochemical	Wan C (2015)	1
AP1M2	2	HEATR5B	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFAP2A	1	AP1M2	2	affinity chromatography technology	Keyel PA (2008)	1
EGFR	5	AP1B1	6	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013)	2
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
APP	1	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
PSEN1	11	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	SCNN1G	2	affinity chromatography technology	Wiemuth D (2007)	1
MAST1	9	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	HECTD1	16	affinity chromatography technology	Huttlin EL (2015)	1
EGFR	5	AP1G1	8	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
AP1M2	2	AP1S1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFAP2A	1	EPN1	4	affinity chromatography technology, pull down	Sugiyama S (2005), Hawryluk MJ (2006)	2
TFAP2A	1	AP2B1	3	affinity chromatography technology	Keyel PA (2008)	1
EPN1	4	AP1M2	2	affinity chromatography technology	Wang H (2006)	1
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
AP1M2	2	MON1A	0	biochemical	Wan C (2015)	1
ECSIT	3	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
NECAP1	0	APP	1	pull down	Olah J (2011)	1
PSEN1	11	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
APP	1	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	AP1S2	1	affinity chromatography technology	Tong J (2014)	1